When a view is active, a red rectangle appears around the view. Keyboard shortcuts and top menu options are associated with the active view. If a menu option is greyed out, it means it does not apply to the layer, drawing or other type of selection or the option does not apply to the active view.
2D Animator and Character Designer
Workspace modifications are automatically saved when you exit the application, unless you disable the Automatically Save Workspace option in the Preferences dialog box.